Mr Ten Divergence Betwixt B Cells Together With Plasma Cells (B Cells Vs Plasma Cells)

B lymphocytes or B cells together with T lymphocytes or T cells are the major players inwards adaptive immune response. T cells mediate prison theater cellular telephone mediated immunity whereas B cells are behind antibody mediated or humoral immunity. They possess antigen binding prison theater cellular telephone surface receptors responsible for specificity, diverseness retention together with self/non-self recognition past times the immune system.
See the Difference betwixt B cells together with T cells

B cells originate together with mature inwards os marrow itself. Two major functions of B cells are

• they differentiate into plasma cells that hit antibodies; together with retention B cells that is responsible for immunologic memory
• B cells acts every bit antigen presenting cells (APCs)

B cells	Plasma cells
B Cells possess a surface B Cell receptor (BCR) composed of surface immunoglobulin (Ig) for antigen binding together with a transmembrane poly peptide made upwardly of 2 heterodimer subunits of Ig-α together with Ig-β  called every bit CD79 for dot transduction	Plasma cells lacks surface receptors similar BCR
B cells are formed from hoematopoetic stalk cells of os marrow	Plasma cells are formed past times the differentiation of B cells upon activation
Naive B cells hit non secrete antibodies	High charge per unit of measurement of secretion of antibodies past times plasma cells
B Cells has MHC shape II receptor every bit it functions every bit antigen presenting cells (APC)	Mature plasma cells lacks MHC shape II receptor
Common mature B prison theater cellular telephone markers are CD19, CD 20, CD21, CD22	Plasma cells ofttimes limited Syndecan1 (CD138), CD44 together with VLA-4 on their surface (common markers)
B cells inwards peripheral lymphoid tissue are predominantly long-lived, amongst a life bridge of betwixt four together with vii weeks	Plasma cells may live short‐lived, surviving solely 3–5 days ofttimes flora inwards the secondary lymphoid tissue. Generally, these secrete lower affinity antibody. Alternatively, plasma cells may live long‐lived, surviving decades or the lifetime of an animal, secreting high‐affinity antibody bulk of which flora inwards the os marrow
*Antibody shape switching together with somatic hypermutation occurs inwards mature B cells inwards reply to antigen stimulation together with costimulatory signals.	No such mechanisms reported then far inwards plasma cells

 *Immunoglobulin shape switching, every bit good known every bit isotype switching, isotypic exchange or class-switch recombination (CSR), is a biological machinery that changes a B cell's production of immunoglobulin (antibodies) from 1 type to another, such every bit from the isotype IgM to the isotype IgG.

Reference

Wang, K., Wei, G., & Liu, D. (2012). CD19: a biomarker for B prison theater cellular telephone development, lymphoma diagnosis together with therapy. Experimental hematology & oncology, 1(1), 36.

Anaya, J. M., Shoenfeld, Y., Rojas-Villarraga, A., Levy, R. A., & Cervera, R. (2013). Autoimmunity: From Bench to Bedside. El Rosario University Press.Fulcher, D. A., & Basten, A. (1997). B prison theater cellular telephone life span: a review. Immunology together with prison theater cellular telephone biology, 75(5), 446-455.Stavnezer, J., Guikema, J. E., & Schrader, C. E. (2008). Mechanism together with rule of shape switch recombination. Annual review of immunology, 26, 261-92.